Merck Manual Professional Framework

The brilliant
diagnostician
at your fingertips.

Clinical decision support that thinks like a consultant.

ClaraDx delivers a full clinical assessment — ICD-10 coded differential diagnosis, SOAP notes, drug interactions, 22 validated clinical scores, FHIR export, and referral letters — in under 60 seconds. Powered by the Merck Manual framework.

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Free for healthcare professionals
No credit card, ever
Works in any browser
ICD-10 coded · Merck Manual ↗
Differential diagnosis
5 diagnoses
1
Acute appendicitis
K35.80
2
Ovarian torsion
N83.52
3
Mesenteric adenitis
I88.0
4
Ectopic pregnancy
O00.9
SOAP note ready Workup plan Red flags ⚠
Wells PE: 4 · CURB-65: 2
Trusted framework
20th
Edition Merck Manual
22
Clinical scoring tools
ICD-10
Coded every diagnosis
FHIR
R4 export standard
<60s
Full assessment
Everything you need

Not just a DDx generator.
A complete clinical workstation.

ClaraDx is the only clinical decision support tool that takes you from chief complaint all the way to a signed referral letter — without switching screens.

🔍
ICD-10 Coded Differential
5–6 ranked diagnoses with ICD-10 codes, pre-test probability, supporting and opposing evidence, and direct Merck Manual chapter links.
📋
Full Intake — 8 Phases
Complete OLDCARTS HPI, past medical history, medications, family and social history, full 14-system ROS, and physical exam — all structured.
⚡
22 Clinical Scoring Tools
Wells PE/DVT, HEART Score, CURB-65, CHA₂DS₂-VASc, qSOFA, PERC, Ottawa Ankle/Foot & Knee Rules, NEXUS, Centor/McIsaac, Glasgow-Blatchford, ABCD², HAS-BLED, San Francisco Syncope Rule, and more — auto-triggered by chief complaint.
💊
Drug Interaction Checker
Full medication list analysis with major, moderate, and minor interactions — mechanism, clinical effect, and management for each pair.
📄
SOAP Note Generator
Auto-populated structured SOAP note from intake data and AI assessment, with physician signature block, ready to copy or export.
🏥
Discharge Summary
Complete hospital discharge documentation with ICD-10 coded diagnoses, medication reconciliation, follow-up instructions, and return precautions.
✉️
Referral Letter Generator
Professional specialist referral letters addressed to any consultant, with clinical summary, specific clinical question, and urgency — ready to send.
🔗
HL7 FHIR R4 Export
Generates a valid FHIR R4 Bundle with Patient, Condition, Observation, MedicationStatement, and DiagnosticReport resources. Downloadable JSON.
👶
Pediatric Mode
Weight-based dosing (mg/kg), pediatric reference ranges, gestational age support, and age-appropriate differential throughout the entire workflow.
See the difference

ClaraDx vs. the competition

Isabel DDx charges $149–$199/year for a basic differential list. ClaraDx delivers a complete clinical workflow — free for healthcare professionals.

Feature
ClaraDx
Isabel DDx
DXplain
ICD-10 coded differential
✓
Partial
✓
Merck Manual references
✓
✓
✗
Full 8-phase clinical intake
✓
✗
✗
22 clinical scoring tools
✓
✗
✗
Drug interaction checker
✓
✗
✗
SOAP note generator
✓
✗
✗
Discharge summary
✓
✗
✗
Specialist referral letter
✓
✗
✗
HL7 FHIR R4 export
✓
✗
✗
PDF export with signature block
✓
✗
✗
Pediatric mode / weight-based dosing
✓
✗
Partial
Works on all devices (no install)
✓
Desktop only (LLM)
✓
Monthly price
Free
$12.42–$16.58
Institutional only
How ClaraDx works

From chief complaint to
complete assessment in 60 seconds.

01
Enter clinical data
Complete the structured 8-phase intake — chief complaint, HPI, PMH, medications, social history, ROS, physical exam, and available test results.
02
AI generates assessment
ClaraDx applies the Merck Manual diagnostic framework to produce a complete ICD-10 coded clinical assessment with red flags, DDx, workup, and management plan.
03
Run clinical tools
Auto-triggered clinical scores, drug interaction checking, Merck Manual reference links, and a real-time probability tracker that updates as new results come in.
04
Export everything
Generate a SOAP note, discharge summary, or referral letter. Export a PDF with physician signature block. Download FHIR R4 JSON for EHR integration.
Free for healthcare professionals

No pricing tiers.
Just register with an email and password.

ClaraDx is in its founding validation phase — it's free for licensed clinicians and students, full stop. No credit card, ever.

✦ Free — no card required
Full access
$0
Every feature, unlimited assessments, for healthcare professionals and students. Register once with an email and password — you're in.
  • Unlimited clinical assessments
  • ICD-10 coded differential diagnosis
  • 22 validated clinical scoring tools
  • Drug interaction checker
  • SOAP note + discharge summary
  • Specialist referral letters
  • HL7 FHIR R4 export
  • PDF export with signature block
  • Pediatric mode
  • Saved cases (up to 25)
Get free access →

No payment info collected, ever · Password set at signup — log in from any device

Built for clinicians

Designed for how
physicians, NPs, and PAs actually work.

⏱

Speed matters at the point of care. ClaraDx delivers a structured OLDCARTS intake and full differential in under 60 seconds — designed to fit between patients, not between appointments.

01
Built for the workflow
Point-of-care speed
⚕

Every differential references the specific Merck Manual chapter and section. Every diagnosis is ICD-10 coded. Every output is reviewable, exportable, and ready for the chart — not a black box.

02
Transparent reasoning
Citation, not speculation
✦

From SOAP notes to specialist referral letters to FHIR R4 export — ClaraDx generates the documentation clinicians actually produce, in the formats EHRs actually accept.

03
End-to-end documentation
From intake to referral

ClaraDx is in early access. Be among the first clinicians to shape how it evolves.

Common questions

Everything you need to know

Is ClaraDx a substitute for clinical judgment? +
No. ClaraDx is a clinical decision-support and educational tool. All outputs must be reviewed by a licensed physician before clinical use. ClaraDx assists clinical reasoning — it does not replace it. Every assessment includes a prominent medical disclaimer.
Which Merck Manual edition does ClaraDx use? +
ClaraDx uses the 20th edition Merck Manual framework — the same diagnostic reasoning structure used in the current Merck Manual Professional Edition at merckmanuals.com/professional — continuously updated. Every differential diagnosis references the specific Merck chapter and section.
Does it work on mobile devices? +
Yes. ClaraDx works in any modern browser on any device — desktop, tablet, or smartphone — with no app installation required. Use it at your workstation, on rounds, or anywhere you have an internet connection.
Is patient data stored or shared? +
ClaraDx is designed as a decision-support tool, not a medical records system. We strongly recommend not entering personally identifiable patient information. Use initials, age, and clinical findings — not names or medical record numbers. See our Privacy Policy for full details.
Is there a catch — will this ever cost money? +
ClaraDx is free for healthcare professionals and students during its founding validation phase, with no payment information collected at signup. If that ever changes for some future tier, existing free accounts would be told in advance — there's no hidden trial clock or surprise charge today.
Is ClaraDx FDA regulated? +
ClaraDx is a clinical decision-support tool intended for use by licensed healthcare professionals as an aid to clinical reasoning. It is designed to be consistent with the FDA's guidance on non-device CDS software — it displays information for review by clinicians rather than making autonomous treatment decisions. Consult your institution's legal counsel regarding specific use cases.
How do I get access? +
Register with your email and a password on the access page and you're in instantly — no verification wait, no card. Use that same email and password to log in on any other device. See our access page or log in if you've already registered.
Can I use ClaraDx for medical education? +
Yes — ClaraDx is excellent for medical students, residents, and clinical educators. The structured intake and Merck Manual-referenced differential diagnosis make it an outstanding teaching tool.

The brilliant diagnostician
at your fingertips.

Join clinicians who have already made ClaraDx part of their daily practice.

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